Whole Genome Sequencing

Your complete genome. One time. For life.

Most genetic tests on the market analyse a fraction of your DNA: between 700,000 and a few million variants. Whole Genome Sequencing (WGS) is different: it reads your complete DNA—the 3.2 billion genetic markers—with 30X coverage using Illumina technology, the global reference standard for genomic sequencing.

It is the most comprehensive and exhaustive genetic analysis that exists. At Health Code, we offer it with a unique and differentiating value on the current market: a personalized interpretation by specialists in integrative/functional medicine, prevention, and anti-aging, as well as recommendations tailored to what your genetics and health need.

What is Whole Genome Sequencing?

Your genome comprises all your genetic information: your genes and the intergenic regions that regulate how they are expressed. Whole Genome Sequencing does not select or filter specific regions: it reads the entire genome. This makes it possible to detect a broad range of genetic variants:

• Single nucleotide variants (SNPs) - the most common ones, present in all DNA tests.
• Variations in the number of copies (CNVs) - duplications or deletions of segments of the genome.
• Insertions and deletions (indels) — variants that genetic arrays do not detect.
• Structural chromosomal anomalies - rearrangements, inversions, translocations.

Why the WGS and not another genetic test?

A quick comparison so you understand the difference:

• Genotyping tests (PRS): analyze up to 700,000 variants — useful as a first step, for polygenic predispositions and global health profiles.
• Exome: analyzes only the genes that code for proteins (∼40 million markers, ∼2% of the genome).
• WGS 30X: 3,200 million markers - 100% of your genome, read 30 times to guarantee maximum reliability.

WGS is the choice when you want the most complete information possible, when you are looking for answers to complex or rare conditions, or when you want all your genomic information available for the future.

A genomic investment for life

Your DNA does not change. Once sequenced, the data are yours forever. This has a huge advantage: as genomic science advances and new associations between variants and diseases are discovered, we will be able to apply that knowledge to your already sequenced genome, without the need to take another sample.

Other more limited tests cannot do this: if in the future a new relevant gene is described that was not on your panel, you will have to repeat the test. With WGS, that does not happen.

How does the process work?

1. You receive your sample collection kit — A simple saliva or blood sample on the finger, collected comfortably at home.
2. Send the sample for sequencing directly to the laboratory — We provide the instructions for you to send your sample. It will be analyzed using next-generation sequencing (NGS) technology with 30X coverage, reading each base of your DNA 30 times to ensure maximum precision and reliability.
3. We receive your raw data — a file containing your genomic information (∼100 GB), stored securely and available to you. It is your complete genetic map.
4. A Health Code specialist interprets your results — We analyze your genome from an integrative perspective (that's what sets us apart from the other available options): predispositions to diseases, pharmacogenetics, nutrition, exercise response, longevity, and much more. We explain it to you in understandable language and with practical, personalized recommendations.

What areas can be analyzed with your WGS?

Thanks to the full availability of the genomic information available, we can explore in depth:

• Health and diseases - predisposition to cardiovascular diseases, cancer, neurodegenerative diseases, autoimmune diseases and more.
• Pharmacogenetics - how you metabolize the most common drugs and how to personalize your treatment.
• Nutrition and metabolism - intolerances, metabolizers, vitamins, minerals, optimal diets.
• Sports performance and recovery.
• Longevity and biological aging.
• Skin health and dermatogenetics.
• Specific genes or specific pathologies — if you have a family history or suspect a specific condition, we can focus the analysis on that area.

Who is it recommended for?

• People who want the most complete and comprehensive genomic information possible.
• Those who have family history of genetic diseases or complex conditions.
• People with difficult to diagnose pathologies or rare diseases.
• Who wants a definitive genetic study that will accompany them for life.
• People interested in precision medicine, longevity and optimization of health from their genomic bases.
• Who have already done other genetic tests and want the maximum level of information.

What this service includes

• Sample collection kit sent to your home.
• 100% sequencing of your genome with 30X coverage (Illumina NGS technology).
• Nutrigenomic interpretation and report
• Interpretation and pharmacogenetics report
• Interpretation and cardiology report
• Interpretation and Oncology report
• Interpretation and report Dermatology and Longevity
• Interpretation and report Gynecology
• Interpretation and report Traumatology
• Interpretation and Neurology report
• Specialized (clinical) genetic report on the area indicated by the patient. This genetic report will be performed by a geneticist on the specific gene or pathology that the client needs us to study.
• File with the complete set of your genomic raw data (∼100 GB) stored securely.
• Personalized clinical interpretation by a Health Code specialist, of all the results obtained, including treatment and practical and actionable recommendations, both short and long term.
• 60-minute results reading session.

Result delivery time: approximately 16 weeks from the receipt of the sample in the laboratory.